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Other disorders that may be related to genetic factors and vitamin deficiencies include fibromyalgia, chronic fatigue syndrome, migraine, rage, depression, bipolar, and other more minor disorders.

How can megadosing with a particular vitamin make up for some genetic errors?

Vitamin must fit tightly in the pocket of the enzyme for full activity. If an enzyme is produced from a gene containing a genetic error (especially in the formation of the vitamin pocket), the error will most likely affect the ability of the enzyme to bind with the vitamin. This will result in reduced enzyme activity, because the vitamin will not be properly fitted to the enzyme. However, enzymologists working in the laboratory have demonstrated a method to force the vitamin into a pocket of an enzyme with low binding affinity. The technique involves raising the concentration of the vitamin, thereby increasing the chance of a productive interaction between the vitamin and its binding site (pocket) on the enzyme. This is precisely what is believed to occur in some of the 50 or so known genetic diseases that are corrected or improved by ingestion of megadoses of vitamins.
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